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血液暨腫瘤科

  • 張育誠醫師相片

    張育誠

    主治醫師

    血液暨腫瘤科 :
    台北門診掛號  淡水門診掛號

    張育誠醫師本頁二維碼

  • 現職

      血液暨淋巴瘤團隊主席,造血幹細胞移植團隊主席
      馬偕紀念醫院 資深主治醫師

    主要學歷

      馬偕醫學院 生物醫學研究所碩士
      中國醫藥大學 醫學士

    主要經歷

      林口長庚紀念醫院 造血幹細胞移植訓練
      血液及骨髓移植專科醫師
      台北榮民總醫院 染色體分析訓練
      台成幹細胞中心 流式細胞分析訓練
      安寧療護專科醫師
      腫瘤內科專科醫師
      血液病專科醫師

    其他相關

      <學會會員>
      台灣內科醫學會
      中華民國癌症醫學會
      中華民國血液病學會
      台灣安寧緩和醫學會
      中華民國血液與骨髓移植學會
      <證書>
      醫師證書
      內科專科醫師證書
      中華民國血液病專科醫師證書
      中華民國腫瘤內科專科醫師證書
      中華民國骨髓移植專科醫師證書

主治項目或專長

血液性疾病 ( 貧血、造血系統疾病、血液凝固及血小板疾病)、骨髓及週邊血液幹細胞移植、造血不良症候群、骨髓增生性疾病、急慢性白血病、淋巴癌、多發性骨髓瘤、 轉移癌症及其它惡性腫瘤、癌症細胞免疫治療。


論文研究

  1. Chang YC*, Tsai HJ, Huang TY, Su NW, Su YW, Chang YF, Chen CG, Lim Johnson, Chang MC, Chen SJ, Chen HC,Chen SJ, Chen HC, Lim KH, Chang KC, Kuo SH. Analysis of mutation profiles in extranodal NK/T-cell lymphoma: clinical and prognostic correlations. Annals of Hematology 2024 Apr 27. doi: 10.1007/s00277-024-05698-9. 

  2. Chang YC*, Chiang YH, Hsu K, Chuang CK, Kao CW, Chang YF, Chang MC, Lim KH, Cheng HI, Hsu YN, Chen CG. Activated naïve γδ T cells accelerate deep molecular response to BCR-ABL inhibitors in patients with chronic myeloid leukemia. Blood Cancer Journal 2021 Nov 16; 11(11): 182.

  3. Lim KH, Wu JN, Huang TY, Jhuang JY, Chang YC*, Lin HC, Chiang YH, Su YW, Chen GS, Chang YF, Lim J. Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing. Blood Adv. 2021 Mar 23; 5(6): 1733-36 

  4. Lim KM, Chen LC, Hsu K, Chang CC, Chang YC*, Kao CW, Chang YF, Chang MC, Chen CG. BAFF-driven NLRP3 inflammasome activation in B cells. Cell Death & Disease 2020 Oct 1; 11(9): 820. 

  5. Chiang YH, Chang YC*, Lin HC, Huang L, Cheng CC, Wang WT, Cheng HI, Su NW, Chen CG, Lin J, Chang YF, Chang MC, Hsieh RK, Chou WC, Lim KH, Kuo YY. Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population. Oncotarget. 2017 Jul 12.

  6. Lim KH, Chen CG, Chang YC*, Chiang YH, Kao CW, Wang WT, Chang CY, Huang L, Lin CS, Cheng CC, Cheng HI, Su NW, Lin J, Chang YF, Chang MC, Hsieh RK, Lin HC, Kuo YY. Increased B cell activation is present in JAK2V617F-mutated, CALR-mutated and triple-negative essential thrombocythemia. Oncotarget. 2017 May 16; 8(20):32476-32491.

  7. Chang YC*, Lin HC, Chiang YH, Chen CG, Huang L, Wang WT, Cheng CC, Lin J, Chang YF, Chang MC, Hsieh RK, Chen SJ, Lim KH, Kuo YY. Targeted next-generation sequencing identified novel mutations in triple-negative myeloproliferative neoplasms. Med Oncol. 2017 May; 34(5):83.

  8. Ken-Hong Lim, Yu-Cheng Chang*, Yi-Hao Chiang, Huan-Chau Lin, Chiao-Yi Chang, Ching-Sung Lin, Ling Huang, Wei-Ting Wang, Caleb Gon-Shen Chen, Wen-Chien Chou, and Yuan-Yeh Kuo*. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Blood Cancer Journal. 2016, Oct; 6, e481.

  9. Ken-Hong Lim, Yu-Cheng Chang*, Yi-Hao Chiang, Huan-Chau Lin, Chiao-Yi Chang, Ching-Sung Lin, Ling Huang, Wei-Ting Wang, Caleb Gon-Shen Chen, Wen-Chien Chou, Yuan-Yeh Kuo. Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. 2016, Oct. The 78th Annual Meeting of the Japanese Society of Hematology, Pacifico Yokohama, Yokohama, Kanagawa Prefecture, Japan.

  10. K-H Lim, Y-C Chang*, C Gon-Shen Chen, H-C Lin, W-T Wang, Y-H Chiang, H-I Cheng, N-W Su, J Lin, Y-F Chang, M-C Chang, R-K Hsieh, Y-Y Kuo and W-C Chou. Frequent CALR exon 9 alterations in JAK2 V617F-mutated essential thrombocythemia detected by high-resolution melting analysis. Blood Cancer Journal. 2015, Mar; 5, e295. 

  11. Ken-Hong Lim, Huan-Chau Lin, Caleb Gon-Shen Chen , Wei-Ting Wang, Yu-Cheng Chang*, Yi-Hao Chiang, Ching-Sung Lin, Nai-Wen Su, Ying-Wen Su, Johnson Lin, Yi-Fang Chang, Ming-Chih Chang, Ruey-Kuen Hsieh, Yuan-Yeh Kuo, Wen-Chien Chou. Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis. Clinica Chimica Acta. 2015, Feb; 440:133-139.

  12. Yu-Cheng Chang*, Ken-Hong Lim, Huan-Chau Lin, Yi-Hao Chiang, Ling Huang, Chen-Wei Kao, Chiao-Yi Chang, Ching-Sung Lin, Nai-Wen Su, Johnson Lin, Ruey-Kuen Hsieh, Ming-Chih Chang, Yi-Fang Chang, Caleb Gon-Shen Chen, Yuan-Yeh Kuo and Wen-Chien Chou. B Cell Immune Profiles in Essential Thrombocythemia with CalrMutations: Clinical and Molecular Correlates. The 57th ASH Annual Meeting and Exposition, Orange County Convention Center, Orlando, FL. Blood. 2015 Dec; 126:1610.

  13. Lim KH, Lin HC, Chiang YH, Wang WT, Lin CS, Chang YC*, Su NW, Chen CS, Lin J, Hsieh RK, Chang MC, Chang YF, Kuo YY, Chou WC. Calr mutations in essential thrombocythemia: frequency, clinical correlation and screening by high-resolution melting analysis. Blood 2014;124:1838.

  14. Lim KH, Lin HC, Chen CG, Wang WT, Chang YC*, Chiang YH, Lin CS, Su NW, Su YW, Lin J, Chang YF, Chang MC, Hsieh RK, Kuo YY, Chou WC. Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis. Clin Chim Acta 2014;440C:133-9.

  15. Huan-Chau Lin, Caleb Gon-Shen Chen, Ming-Chih Chang, Wei-Ting Wang, Chen Wei Kao, An-Chi Lo, Nai-Wen Su, Yu-Cheng Chang*, Yi-Hao Chiang, Kuei-Fang Chou, Po-Nien Liao, Guan-Jhe Cai, Hung-I. Cheng, Johnson Lin, Yi-Fang Chang, Ruey-Kuen Hsieh, Ken-Hong Lim. Mutation and lineage analysis of DNMT3A in BCR-ABL1-negative chronic myeloproliferative neoplasms. International Journal of Gerontology. 2013, Sep; 7(3), 186-188.

  16. Lin HC, Chen CGS, Chang MC, Wang WT, Kao CW, Lo AC, Su NW, Chang YC*, Chiang YH, Chou KF, Liao PN, Cai GJ, Cheng HI, Lin J, Chang YF, Hsieh RK, Lim KH. JAK2 V617F mutation in adult Taiwanese patients with essential thrombocythemia: More prevalent in old patient and correlated with higher hemoglobin level and higher leukocyte count. International Journal of Gerontology 2013;7.

  17. Hsu K, Lin YC, Chang YC*, Chan YS, Chao HP, Lee TY, Lin M. A direct blood polymerase chain reaction approach for the determination of GP.Mur (Mi.III) and other Hil+ Miltenberger glycophorin variants. Transfusion 2013;53:962-71.

  18. Lin HC, Lim KH, Chiang YH, Wang WT, Lin CS, Chang YC*, Hsieh RK, Kuo YY, Chou WC. The role of tet2 DNA methylcytosine dioxygenase in zebrafish early hematopoiesis. Blood 2013;122:1204.

  19. Yu-Cheng Chang*, Nai-Wen Su, Hong-Yi Zheng, Huan-Chao Lin, Jian-Hong Lim, Yi-Fang Chang, Johnson Lin, Ruei-Kun Hsie, Ming-Chin Chang, Gon-Shen Chen. CHOP plus L-asparaginase for Patients with Peripheral T-cell Lymphoma. J. Cancer Res. Pract. 27(3),93-99, 2011.

  20. Yu-Cheng Chang*, HY Cheng, YH Chiang, NW Su, MC Chang, CG Chen, HT Lin, J Lin, KH Lim, RK Hsie, YF Chang. Multivariate Analysis of Blood Cells in Patients with Myelodysplastic Syndromes. 中華民國血液病學會第147次聯合學術研討會(100年會)